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A solution of 100 g of 2.5-DIMETHOXYPHENETHYLAMINE in 220 g nitromethane was treated with 10 g anhydrous ammonium acetate and heated on a steam bath for 2.5 h with occasional swirling.

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2C-B (2.5-DIMETHOXYPHENETHYLAMINE) is a psychedelic drug of the 2C family.
It was first synthesized by Alexander Shulgin in 1974.
In Shulgin’s book PiHKAL, the dosage range is listed as 12–24 mg.
As a recreational drug, 2C-B is sold as a white powder sometimes pressed in tablets or gel caps and is also referred to by a number of other names.
The drug is usually taken orally, but can also be snorted (insufflated) or vaporized.


A solution of 100 g of 2.5-DIMETHOXYPHENETHYLAMINE in 220 g nitromethane was treated with 10 g anhydrous ammonium acetate and heated on a steam bath for 2.5 h with occasional swirling. The deep-red reaction mixture was stripped of the excess nitromethane under vacuum, and the residue crystallized spontaneously. This crude nitrostyrene was purified by grinding under IPA, filtering, and air-drying, to yield 85 g of 2,5-dimethoxy-beta-nitrostyrene as a yellow-orange product of adequate purity for the next step. Further purification can be achieved by recrystallization from boiling IPA.

The common oral recreational dose is around 15–25 mg, at which visual and auditory effects are experienced. Severe adverse reactions are extremely rare, but the use of 2C-B has been linked to significant brain injury in one case where the dosage was unknown, and the purity of the chemical was not verified.

Oral Insufflated
ED50 10 mg 4–6 mg
Moderate 15–25 mg 5–9 mg
Strong 26–35 mg 10–20 mg
Extremely Intense >35 mg >20 mg
Duration 4–8 hours 2–4 hours


When orally consumed, 2C-B has a much longer delay before the onset of effects than when it is insufflated. Oral ingestion generally takes roughly 45–75 minutes for the effects to be felt, plateau lasts 2–4 hours, and coming down lasts 1–2 hours. Rectal administration onset varies from 5–20 minutes. Insufflated onset takes 1–10 minutes for effects to be felt. The duration can last from 4 to 12 hours depending on the route of administration, dose, and other factors.

With insufflation, the effects are more abrupt and intense but have a significantly shorter duration, while oral usage results in a milder, longer experience. When insufflated, the onset happens very rapidly, usually reaching the peak at about 20–40 minutes and plateauing for 2–3 hours. 2C-B is also considered one of the most painful drugs to insufflate, with users reporting intense nasal burning. The sudden intensity of the experience combined with the pain can often start the experience with a negative imprint and nausea is also increased with insufflation, compounding the issue


(with 16 mg) “A day at the Stanford museum. Things were visually rich, yet I felt that I was reasonably inconspicuous. The Rodin sculptures were very personal and not terribly subtle. I saw Escher things in the ceiling design when I decided to sit in a foyer somewhere and simply pretend to rest. Walking back, the displays are seen in the bark of the eucalyptus trees, and the torment and fear (of others? of themselves?) in the faces of those who were walking towards us, were as dramatic as anything I had seen in the art galleries. Our appetites were enormous, and we went to a smorgasbord that evening. A rich experience in every possible way.”


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