What is 3-Methoxyphencyclidine ( 3-MeO-PCP)?
3-Methoxyphencyclidine (also known as 3-MeO-PCP) is a lesser-known novel dissociative substance of the arylcyclohexylamine class. 3-MeO-PCP is a derivative of phencyclidine (PCP) and is chemically related to substances like methoxetamine and 3-MeO-PCE. It produces its effects by blocking NMDA receptors in the brain.
3-MeO-PCP was first synthesized in 1979 in an investigation of phencyclidine (PCP) derivatives. However, its activity in humans was not described until 1999 when a chemist using the pseudonym John Q. Beagle reported qualitative similarities to PCP along with comparable potency. In 2009, it began to be discussed on online forums such as bluelight.ru and was made available for sale on the research chemicals market.
Like other arylcyclohexylamines, 3-MeO-PCP induces a state referred to as “dissociative anesthesia”, although the extent to which this occurs is reported to be highly dose-dependent and variable in its effects. It is commonly taken orally and nasally, although it may also be smoked and injected. It has been noted for its subtle come-up and tendency to produce delusions of sobriety, which can lead to compulsive redosing.
Very little data exists for the pharmacology, metabolism, and also toxicity of 3-MeO-PCP. Due to its potent hallucinogenic effects and lack of research, it is strongly advised to use harm reduction practices if using this substance.
3-Methoxyphencyclidine, or 3-MeO-PCP, is a synthetic dissociative of the arylcyclohexylamine class. 3-MeO-PCP contains cyclohexane, a six-membered saturated ring, bonded to two additional rings at R1. One of these rings is a piperidine ring, a nitrogenous six-member ring, bonded at its nitrogen group. The other ring is an aromatic phenyl ring, substituted at R3 with a methoxy group.
3-MeO-PCP is a PCP derivative and structurally analogous to 4-MeO-PCP
3-MEO-PCP is consumed in sniff, oral, IM, IV or plug. It is soluble in water.
Oral sniff plug
Threshold 1,5-3mg 1-2mg 1-2mg
Lightweight 3-5mg 2-5mg 2-4mg
par 5-10mg 5-8mg 4-7mg
strong 10-15mg 8-12mg 7-11mg
Very strong + 15-20 mg + 12-15 mg + 11-14 mg
Although many psychoactive substances are safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The following lists some known dangerous combinations, but may not include all of them. A combination that appears to be safe in low doses can still increase the risk of injury or death. Independent research should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from Trips.
Stimulants – Both stimulants and dissociatives carry the risk of adverse psychological reactions like anxiety, mania, delusions, and psychosis, and these risks are exacerbated when the two substances are combined.
Depressants – Because both depress the respiratory system, this combination can result in an increased risk of suddenly falling unconscious, vomiting, and choking to death from the resulting suffocation. If nausea or vomiting occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.
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